Publications by authors named "J Liebich"

Objective: Patients with Cystic Fibrosis related diabetes [CFRD] are treated with insulin and high calorie diets to maintain body mass. The combined CFTR modulator elexacaftor/tezacaftor/ivacaftor [ETI] decreases pulmonary exacerbations and improves nutritional status. We reviewed the effects of ETI on BMI, HbA1c and diabetes regimen in patients with CFRD over a period of three years.

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The skate Leucoraja erinacea has an elaborately shaped pupil, whose characteristics and functions have received little attention. The goal of our study was to investigate the pupil response in relation to natural ambient light intensities. First, we took a recently developed sensory-ecological approach, which gave us a tool for creating a controlled light environment for behavioural work: during a field survey, we collected a series of calibrated natural habitat images from the perspective of the skates' eyes.

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Article Synopsis
  • Meningiomas, the most common primary brain tumors, have a specific mutation in the AKT1 gene that leads to aggressive forms and earlier tumor recurrence.
  • This study investigates how the AKT1 mutation affects tumor growth and response to treatment with the Akt inhibitor AZD5363 in laboratory models.
  • Results showed that the AKT1 mutation boosts cancer cell growth and decreases survival in mice, but AZD5363 treatment significantly reduces cell growth and improves survival, indicating its potential as a targeted therapy for these tumors.
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Investigating retinal specializations offers insights into eye functionality. Using retinal wholemount techniques, we investigated the distribution of retinal ganglion cells in the Little skate Leucoraja erinacea by (a) dye-backfilling into the optic nerve prior to retinal wholemounting; (b) Nissl-staining of retinal wholemounts. Retinas were examined for regional specializations (higher numbers) of ganglion cells that would indicate higher visual acuity in those areas.

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