The Possibility of Using Oil Pomace as a Substitute for Walnuts ( L.) in Muesli Bar Technology.

The utilization of food industry waste to create innovative, high-quality products with reduced environmental impact is a growing trend in food technology. Walnut oil pomace, a byproduct of walnut oil production, is rich in nutrients and bioactive compounds, making it an excellent candidate for reuse in muesli bars as a replacement for walnuts. The aim of the study was to evaluate the possibility of replacing walnuts with oil pomace in muesli bar recipes and to assess whether the resulting product meets quality standards.

Pressure pain threshold of the mastigatory muscles and reaction to touch in adults with down syndrome and neurotypicals: cross-sectional study.

Background: Down Syndrome (DS) is currently the most common chromosomal condition associated with intellectual disability in the global population and is characterized by a variety of additional clinical findings. Individuals with DS may exhibit altered perception and reaction to painful stimuli, which makes the diagnosis of pain in DS a challenge. This study aimed to evaluate the pressure pain threshold of the masticatory muscles and the reaction to social touch in individuals with DS compared to neurotypical individuals (NT).

Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions.

C9orf72 repeat expansions are the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Poly(GR) proteins are toxic to neurons by forming cytoplasmic inclusions that sequester RNA-binding proteins including stress granule (SG) proteins. However, little is known of the factors governing poly(GR) inclusion formation.

Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress.

Alzheimer's disease and related tauopathies are characterized by the pathogenic misfolding and aggregation of the microtubule-associated protein tau. Understanding how endogenous chaperones modulate tau misfolding could guide future therapies. Here, we show that the immunophilin FKBP12, the 12-kDa FK506-binding protein (also known as FKBP prolyl isomerase 1A), regulates the neuronal resilience by chaperoning a specific structure in monomeric tau.