Publications by authors named "J Li-Yu"
Introduction: Triple semicircular canal plugging is effective in controlling vertigo in patients with Meniere's disease, however, whether the rate of causing hearing loss during treatment is still not uniform. This study aimed to evaluate the effects of Triple semicircular canal plugging (TSCP) on hearing in Meniere's disease (MD) patients.
Methods: Databases Reviewed were PubMed, EMBASE, Scopus, Clinical Trials, Web of Science, Cochrane Library, CNKI, Wanfang, and VIP.
Article Synopsis
- Social isolation in mice over a period of 8 weeks led to depressive and anxiety-like behaviors, cognitive impairment, and decreased levels of m6A modifications in the hippocampus, along with reduced expression of the enzyme METTL14.
- The study quantified m6A levels and analyzed the effects of over-expressing METTL14 using a viral tool, which showed that restoring METTL14 levels improved mood and cognitive functions in socially isolated mice.
- These findings suggest that m6A modifications and the enzyme METTL14 play a critical role in addressing social isolation-induced behavioral impairments, indicating potential targets for therapeutic strategies in managing related mental health issues.
Osteoporosis is highly prevalent, particularly in developing countries. However, bone turnover marker reference ranges for management of osteoporosis in Asian population are yet to be explored and established. Thus, this study aims to develop a regional bone turnover markers (BTMs) reference database by combining country-specific reference database from five ASEAN countries: Malaysia, the Philippines, Singapore, Thailand, and Vietnam.
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- - The study aims to create a consensus in the Asia-Pacific region on long-term management and sequential therapy for osteoporosis, focusing on effective fracture prevention through individualized treatment strategies.
- - A panel of experts analyzed current literature and expert opinions, resulting in 12 key recommendations, such as using anabolic agents for high fracture risk patients and switching to antiresorptive agents post-anabolic therapy if needed.
- - The findings offer a cost-effective framework for osteoporosis management, emphasizing shared decision-making and integration of local healthcare systems to enhance patient care in the Asia-Pacific region.