A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma.

So far, no common environmental and/or phenotypic factor has been associated with melanoma and renal cell carcinoma (RCC). The known risk factors for melanoma include sun exposure, pigmentation and nevus phenotypes; risk factors associated with RCC include smoking, obesity and hypertension. A recent study of coexisting melanoma and RCC in the same patients supports a genetic predisposition underlying the association between these two cancers.

[One case of type 1 auto-immune polyendocrinopathy or APECED].

Introduction: autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED) is a rare autosomal recessive disorder caused by mutations in the autoimmune regulator gene (AIRE). We report the case of a young girl with APECED.

Case Report: an 18 year-old girl born to consanguineous parents consulted for diffuse alopecia.

[Biological therapy for psoriasis: practical experience at a French dermatology unit].

Background: The course of biological therapy (BT) in clinical practice may differ markedly from treatment schedules in clinical trials. Treatment modifications and patient characteristics can affect treatment safety and efficacy. In addition, long-term results concerning the use of BT in clinical practice are lacking.

[Pandalao and skin whitening in Mayotte].

Introduction: Skin whitening (SW) is very common in dark-skinned populations and the practice is often named after a popular local brand of product and such is the case in Mayotte where this practice is called "pandalao".

Patients And Methods: We carried out a descriptive epidemiological study in a sample of black Mahoran women aged 15 and over. The survey comprised a questionnaire completed by 163 women between 12 November 2007 and 24 January 2008.