The Trimeric Autotransporter Adhesin YadA of Serotype O:9 Binds Glycan Moieties.

adhesin A (YadA) is a key virulence factor of and . YadA is a trimeric autotransporter adhesin, a class of adhesins that have been shown to enable many Gram-negative pathogens to adhere to/interact with the host extracellular matrix proteins such as collagen, vitronectin, and fibronectin. Here, we show for the first time that YadA of serotype O:9 not only interacts with proteinaceous surface molecules but can also attach directly to glycan moieties.

A review on impedimetric immunosensors for pathogen and biomarker detection.

Since the discovery of antibiotics in the first quarter of the twentieth century, their use has been the principal approach to treat bacterial infection. Modernized medicine such as cancer therapy, organ transplantation or advanced major surgeries require effective antibiotics to manage bacterial infections. However, the irresponsible use of antibiotics along with the lack of development has led to the emergence of antimicrobial resistance which is considered a serious global threat due to the rise of multidrug-resistant bacteria (Wang et al.