JAK1 Is a Novel Target of Tumor- and Invasion-Suppressive microRNA 494-5p in Colorectal Cancer.

MiR-494-5p expression has been suggested to be associated with colorectal cancer (CRC) and its metastases in our previous studies. However, functional investigations on the molecule-mediating actions of this miR in CRC are lacking. In silico analysis in the present study revealed a putative binding sequence within the 3'UTR of JAK1.

ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo.

Objective: Mucosal T cells play a major role in inflammatory bowel disease (IBD). However, their immunometabolism during intestinal inflammation is poorly understood. Due to its impact on cellular metabolism and proinflammatory immune cell function, we here focus on the enzyme ATP citrate lyase (ACLY) in mucosal T cell immunometabolism and its relevance for IBD.

Fourier transform temporal diffusion spectroscopy.

Temporal diffusion spectroscopy (TDS) currently uses the oscillating gradient spin echo (OGSE) experiment to measure the spectral density of translational velocity autocorrelation at single frequencies. Due to timing restrictions imposed by the transverse relaxation, the frequency selectivity and the sampling density of OGSE are limited, especially at low frequencies. We propose to overcome this problem by adopting the principles of Fourier transform spectroscopy.

On the noise in "augmented T1-weighted steady state magnetic resonance imaging".

Recently, Ye and colleagues proposed a method for "augmented T1-weighted imaging" (aT W). The key operation is a complex division of gradient-echo (GRE) images obtained with different flip angles. Ye and colleagues provide an equation for the standard deviation of the obtained aT W signal.