Publications by authors named "J Letheulle"
Article Synopsis
- Enterococcus faecalis infective endocarditis (EFIE) has a higher relapse rate compared to other types of infective endocarditis, and this study explores the influence of different antibiotic treatments on these relapses.
- The research involved 279 patients from 14 hospitals in France, analyzing the occurrence of relapses within one year following diagnosis, using specific statistical models to account for competing risks like death.
- Results showed that relapses are common (9.3% in one year) and can even be asymptomatic, with surgery during treatment noted as a protective factor; the relapse rates varied significantly based on the type of antibiotic regimen used.
Article Synopsis
- Evacuation of infected fluid in pleural infections is crucial, and this study examines the effects of using a combination of intrapleural urokinase and DNase compared to urokinase alone in patients undergoing repeated therapeutic thoracentesis (RTT).
- The study involved 133 patients treated from 2001 to 2018, revealing no significant difference in treatment failure rates or mortality between the two groups, but faster recovery and shorter hospital stays for those receiving the combination therapy.
- The findings suggest that adding DNase to urokinase may improve recovery outcomes in pleural infection treatments, though further randomized controlled trials are needed to validate these results.
Background: Moderate therapeutic hypothermia is currently recommended to improve neurologic outcomes in adults with persistent coma after resuscitated out-of-hospital cardiac arrest. However, the effectiveness of moderate therapeutic hypothermia in patients with nonshockable rhythms (asystole or pulseless electrical activity) is debated.
Methods: We performed an open-label, randomized, controlled trial comparing moderate therapeutic hypothermia (33°C during the first 24 hours) with targeted normothermia (37°C) in patients with coma who had been admitted to the intensive care unit (ICU) after resuscitation from cardiac arrest with nonshockable rhythm.
Introduction: The aim of our study was to compare the features at diagnosis in patients with ornithosis to patients with avian acute hypersensitivity pneumonitis (HP). Clinical, biological and radiological differences could potentially help clinicians to distinguish these diseases.
Methods: We conducted a retrospective study on patients admitted from 2000 to 2016 in three hospitals.
Purpose: Data for ANCA-associated vasculitis (AAV) patients requiring intensive care are scarce.
Methods: We included 97 consecutive patients with acute AAV manifestations (new onset or relapsing disease), admitted to 18 intensive care units (ICUs) over a 10-year period (2002-2012). A group of 95 consecutive AAV patients with new onset or relapsing disease, admitted to two nephrology departments with acute vasculitis manifestations, constituted the control group.