Publications by authors named "J Leppert"

Background: Prevention is a cornerstone for management of recurrent urinary stone disease. Current guidelines recommend metabolic evaluation, lifestyle modification, and medical treatment for patients with urinary stone disease. Nephrologists are uniquely qualified to evaluate stone risk and formulate treatment strategies to reduce that risk.

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Importance: Men with limited life expectancy (LE) have historically been overtreated for prostate cancer despite clear guideline recommendations. With increasing use of active surveillance, it is unclear if overtreatment of men with limited LE has persisted and how overtreatment varies by tumor risk and treatment type.

Objective: To determine if rates of overtreatment of men with limited LE have persisted in the active surveillance era and whether overtreatment varies by tumor risk or treatment type.

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Background: Prostate cancer is the most common cancer among men in the United States, yet modifiable risk factors remain elusive. In this study, the authors investigated the potential role of agricultural pesticide exposure in prostate cancer incidence and mortality.

Methods: For this environment-wide association study (EWAS), linear regression was used to analyze county-level associations between the annual use of 295 distinct pesticides (measured in kg per county) and prostate cancer incidence and mortality rates in the contiguous United States.

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Background/aim: Xerostomia following (chemo-) radiotherapy (CRT) is common in head and neck (HNC) patients. This prospective study focused on investigating the link between salivary gland function and the onset of malnutrition in HNC patients.

Patients And Methods: Between 2018 and 2020, 61 HNC patients scheduled for curative CRT were prospectively recruited.

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Article Synopsis
  • This study investigates the impact of presurgical tumor growth and other clinical factors on the survival of glioblastoma (GBM) patients.
  • A retrospective analysis of 98 adult GBM patients revealed that tumor growth rates did not significantly affect overall survival (OS) or progression-free survival (PFS).
  • Key predictors of treatment outcomes included MGMT status, radiation dose, and the number of adjuvant cycles of temozolomide (TMZ), which can help inform personalized treatment plans.
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