Obesity-related cellular stressors regulate gonadotropin releasing hormone gene expression via c-Fos/AP-1.

Obesity is a risk factor for infertility, but mechanisms underlying this risk are unclear. Fertility is regulated by hypothalamic gonadotropin-releasing hormone, encoded by the Gnrh1 gene. Because obesity promotes endoplasmic reticulum (ER) stress, we sought to determine how tunicamycin-induced ER stress affected Gnrh1 gene expression in the mouse hypothalamic cell line GT1-7.

Radiology of arthritis.

The radiographic evaluation of the arthritides still relies primarily on the plain films that are readily available to every practicing clinician. The radiographic examination serves primarily to confirm the clinician's diagnosis based on the history, clinical findings, and laboratory studies and to document the severity of the arthritic changes. On occasion, the radiographic studies will be diagnostic when other findings are equivocal and the diagnosis is in question.

Diagnosis of a ruptured deep femoral artery aneurysm--a case report.

Deep femoral artery aneurysms are rarely atherosclerotic in origin and infrequently rupture. A case of spontaneous rupture of an isolated deep femoral atherosclerotic aneurysm is presented. The computed tomographic, angiographic, and clinical findings are discussed.