Publications by authors named "J Lenhard"
The feasibility of repurposing selective serotonin reuptake inhibitors as adjunctive antibacterial agents is an area of current investigation. We sought to evaluate if fluoxetine will achieve synergistic killing with relevant antibacterial drugs against skin and soft tissue pathogens and multidrug-resistant pathogens. : The MIC of fluoxetine was determined using broth microdilution for a diverse isolate collection of 21 organisms.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess how effective β-lactam antibiotics, like ampicillin and cefazolin, are against a mix of clinically important gram-positive and gram-negative bacteria, particularly in the presence of bacterial enzymes called β-lactamases that can inactivate these drugs.
- Researchers tested various bacterial isolates in experiments to see how well these antibiotics worked alone and when bacteria with different β-lactamase production profiles were present.
- The results showed that the effectiveness of both antibiotics decreased significantly in the presence of β-lactamase-producing bacteria, highlighting how these enzymes can protect other bacteria from antibiotic treatment.
A child of prediction. On the History, Ontology, and Computation of the Lennard-Jonesium.
Stud Hist Philos Sci
February 2024
The Lennard-Jones (LJ) fluid, named after mathematician-physicist-chemist Sir John Lennard-Jones (1894-1954), occupies a special place among fluids. It is an ideal entity, defined as the fluid whose particles interact according to the Lennard-Jones potential. This paper expounds the history of the LJ fluid to throw light on the tensions between theory and computational practice.
View Article and Find Full Text PDFThe continuing need for the discovery of potent antibacterial agents against antibiotic-resistant pathogens is the driving force for many researchers to design and develop such agents. Herein, we report the design, synthesis, and biological evaluation of amidine derivatives as new antibacterial agents. Compound was the most active in this study against a wide range of antibiotic-resistant, and susceptible, Gram-positive, and Gram-negative bacterial strains.
View Article and Find Full Text PDFis a difficult-to-treat pathogen that is frequently involved with chronic wound infections. Here, we conducted a literature search of world-wide studies published between 2005 and 2022 that described the microbiological profiles of chronic wound infections. For each continent, a hierarchy of pathogens was created to define the organisms that were most frequently isolated in each region.
View Article and Find Full Text PDF