A Web-Based Survey of Patients Dispensed Viagra Connect Behind the Counter in UK: An Evaluation of Effectiveness of Additional Risk Minimization Measures.

Purpose: A national additional risk minimization measures (aRMMs) program was implemented to train pharmacists for safe supply of non-prescription Viagra Connect (VC) to erectile dysfunction (ED) patients in United Kingdom (UK). A survey aimed to evaluate the effectiveness of aRMMs.

Methods: A cross-sectional, web-based survey enrolled ED patients who purchased at least 1 supply of VC in UK, using a structured self-administered questionnaire.

Dynamic diagnosis of metamaterials through laser-induced vibrational signatures.

Mechanical metamaterials at the microscale exhibit exotic static properties owing to their engineered building blocks, but their dynamic properties have remained substantially less explored. Their design principles can target frequency-dependent properties and resilience under high-strain-rate deformation, making them versatile materials for applications in lightweight impact resistance, acoustic waveguiding or vibration damping. However, accessing dynamic properties at small scales has remained a challenge owing to low-throughput and destructive characterization or lack of existing testing protocols.

High-power laser beam shaping using a metasurface for shock excitation and focusing at the microscale.

Achieving high repeatability and efficiency in laser-induced strong shock wave excitation remains a significant technical challenge, as evidenced by the extensive efforts undertaken at large-scale national laboratories to optimize the compression of light element pellets. In this study, we propose and model a novel optical design for generating strong shocks at a tabletop scale. Our approach leverages the spatial and temporal shaping of multiple laser pulses to form concentric laser rings on condensed matter samples.

Converging-diverging shock-driven instabilities along soft hydrogel surfaces.

Intense surface eruptions are observed along the curved surface of a confined cylindrical film of hydrogel subject to laser-induced converging-diverging shock loading. Detailed numerical simulations are used to identify the dominant mechanisms causing mechanical instability. The mechanisms that produce surface instability are found to be fundamentally different from both acoustic parametric instability and shock-driven Richtmyer-Meshkov instability.