Chronopharmacokinetics of indomethacin in rats.

In order to establish the origin of the circadian variations in the kinetics of indomethacin (Indocid) observed in humans, a chronopharmacokinetic study was developed in rats. In a first experiment, 3 groups of 24 h fasted rats each received a single i.v.

[Pharmacokinetics of 35S-furosemide in experimental kidney failure in the rat].

Pharmacokinetics of 35S-Furosemide were determined after a single intravenous administration (2,5 mg/kg) in rats with experimental renal insufficiency due to figure in S-ligation of the kidney or subcutaneous injection of uranyl nitrate (10 mg/kg) in uninephrectomized animals. In the rat the pharmacokinetics of Furosemide obeyed to a two-compartment model. The distribution parameters were not markedly altered by renal insufficiency while the elimination ones were decreased proportionally to the renal impairment.

Pharmacokinetics of intravenous camazepam in dogs.

Free plasma concentrations were studied after i.v. administration of three different doses (2.

Pharmacokinetics and bioavailability of pyridinol carbamate in humans.

The pharmacokinetics of two pyridinol carbamate formulations were studied after a single oral administration in 10 healthy volunteers. An open one-compartment model described the evolution of plasma concentrations as a function of time. Pyridinol carbamate was rapidly absorbed (mean lag time from 0.

Pharmacokinetics of fenbufen in man.

The pharmacokinetics of fenbufen (3,4-biphenylcarbonyl proprionic acid) a new antiinflammatory agent, and its metabolites, gamma-hydroxy-4-biphenylbutyric acid and 4-biphenylacetic acid have been studied after oral administration to seven patients with rheumatoid arthritis. Fenbufen was administered as a single oral dose of 600 mg in hard gelatine capsules. A specific, sensitive gas chromatographic method was used to measure the concentration of the three compounds.