Publications by authors named "J Lefkowitch"
Article Synopsis
- The study investigates the impact of rare genetic variants on the development of advanced fibrosis in pediatric patients with Nonalcoholic Fatty Liver Disease (NAFLD), since common associations in adults are not well understood for children.
- Whole exome sequencing was performed on 229 pediatric NAFLD patients to identify any significant differences in rare genetic variants between those with advanced fibrosis and those without; however, no significant associations were found.
- The results indicate a lack of correlation between rare genetic variants and advanced fibrosis or other histologic features in children, including the previously studied genes in adults, suggesting limitations in the ability to detect these associations due to sample size.
IgG4 plasma cell neoplasm and myeloma are rare disease entities, not associated with systemic fibroinflammatory IgG4 related disease. We herein present a case of IgG4 plasma cell neoplasm in a liver transplant biopsy. A 55 year old female was treated with living donor transplant and had a complicated post-operative course.
View Article and Find Full Text PDFBackground And Aims: Vibration-controlled transient elastography (VCTE) is a noninvasive tool that uses liver stiffness measurement (LSM) to assess fibrosis. Since real-life data during everyday clinical practice in the USA are lacking, we describe the patterns of use and diagnostic performance of VCTE in patients at an academic medical center in New York City.
Methods: Patients who received VCTE scans were included if liver biopsy was performed within 1 year.
The preparation of student-authored autopsy reports of anatomical donors was added to the Gross Anatomy course to integrate the basic and clinical sciences and determine whether students considered this early clinical exposure to be a valuable experience. All donors were scanned using computerized tomography (CT) and student groups received the scan of their donor and a report written by a radiologist. As students dissected, they took photographs and biopsies of pathological findings that were processed for microscopic evaluation.
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