Publications by authors named "J Lebret"

In this needs assessment, gathered patient perceptions on how telemedicine video visits might influence their care. Patients in this study (n = 13) were all diagnosed with end-stage cancer and were receiving palliative care at an urban academic medical center. Interview themes addressed: 1.

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Article Synopsis
  • Central pattern generators (CPGs) in the spinal cord are responsible for coordinating the limb movements necessary for walking.
  • Mice missing the EphA4 receptor or its ligand ephrinB3 exhibit a loss of normal left-right limb alternation and display uncoordinated synchrony during locomotion.
  • The research highlights EphA4-positive neurons as essential excitatory components of the locomotor CPG, revealing that genetic changes can significantly impact locomotion and identifying key genes important for normal walking behavior.
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Neuronal circuits involved in left-right coordination are a fundamental feature of rhythmic locomotor movements. These circuits necessarily include commissural interneurons (CINs) that have axons crossing the midline of the spinal cord. The properties of CINs have been described in some detail in the spinal cords of a number of aquatic vertebrates including the Xenopus tadpole and the lamprey.

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