Publications by authors named "J Leb"
Unusual presentation of rearranged metastatic non-small cell lung cancer.
Respir Med Case Rep
August 2024
The spectrum of clinical and radiographic presentations of lung adenocarcinoma is increasingly broad, including in the metastatic setting. Here, we report on a patient who initially presented with a mild chronic cough that remained stable over a decade, with serial CT scans showing gradual worsening of multifocal areas of consolidation and ground-glass opacities of the bilateral lungs. The patient was ultimately diagnosed with rearranged lung adenocarcinoma and achieved a dramatic response with entrectinib.
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- Preoperative assessment of pectoralis muscle area, which estimates sarcopenia, is linked to increased risks in LVAD patients, including higher postoperative mortality and gastrointestinal bleeding.
- A study involving 254 LVAD patients found that those with low pectoralis muscle area (low-PMI cohort) exhibited significantly elevated inflammation and endotoxemia markers compared to others.
- Patients with low pectoralis muscle area experienced longer hospital stays and a greater likelihood of readmissions within 90 days and one year after surgery.
Article Synopsis
- This study compares two methods of estimating kidney function (eGFRcysC and eGFRsCr) in heart transplant recipients, focusing on how body mass index (BMI), steroid use, and muscle mass affect accuracy.
- Significant differences between the two eGFRs were noted, especially early after transplantation, with eGFRcysC showing more stability over time compared to eGFRsCr.
- Using eGFRcysC can impact dosing for the medication valganciclovir, suggesting that 46% of patients would have required dosage adjustments, mostly reductions, highlighting the importance of accurate kidney function assessment.
Absence of long-term structural and functional cardiac abnormalities on multimodality imaging in a multi-ethnic group of COVID-19 survivors from the early stage of the pandemic.
Eur Heart J Imaging Methods Pract
September 2023
Article Synopsis
- Many COVID-19 survivors from the early pandemic showed signs of cardiac injury, prompting investigations into long-term heart effects using cardiac imaging techniques like CMR and TTE.
- A study involving 40 COVID-19 survivors and 12 matched controls conducted TTE and CMR at an average of 308 days post-infection, revealing no significant differences in heart structure, function, or tissue abnormalities between the groups.
- The findings suggest that there is no lasting damage or inflammation to the heart in these survivors, despite previous reports of cardiac issues during acute COVID-19.
Article Synopsis
- Fibrosis is the abnormal buildup of connective tissue due to improper healing from injuries like lack of oxygen, infections, or trauma, affecting any organ and leading to dysfunction and failure.
- It also plays a significant role in cancer development, making early diagnosis and monitoring vital for improving patient outcomes.
- This paper specifically examines fibrosis in the genito-urinary system, highlighting current imaging technologies for detection and suggesting possible future research directions.