Publications by authors named "J Le Guilloux"
Article Synopsis
- A trial was conducted to assess the effects of the EXOPULSE Mollii Suit, a device that provides electrical nerve stimulation, on fibromyalgia symptoms including pain, fatigue, and quality of life.
- The study involved 33 adult patients with fibromyalgia in a double-blind, sham-controlled trial, demonstrating significantly reduced pain and improved symptoms after using the active device compared to the sham treatment.
- Results showed that after a 4-week active treatment period, most patients reported improvements in various outcomes, highlighting the potential clinical benefits of the EXOPULSE Mollii Suit for managing fibromyalgia symptoms.
(R,S)-ketamine (ketamine) has rapid and sustained antidepressant (AD) efficacy at sub-anesthetic doses in depressed patients. A metabolite of ketamine, including (2R,6R)-hydroxynorketamine ((6)-HNKs) has been reported to exert antidepressant actions in rodent model of anxiety/depression. To further understand the specific role of ketamine's metabolism in the AD actions of the drug, we evaluated the effects of inhibiting hepatic cytochrome P450 enzymes on AD responses.
View Article and Find Full Text PDFKetamine, a non-competitive antagonist of the N-methyl-D-aspartate-glutamate receptor (R-NMDA), has a rapid (from 24 h post-dose) and prolonged (up to one week) antidepressant effect in treatment resistant depression and in rodent models of anxiety/depression. Arguments regarding its cellular and molecular mechanisms underlying its antidepressant activity mainly come from animal studies. However, debates still persist on the structural remodeling of frontocortical/hippocampal neurons and the role of excitatory/inhibitory neurotransmitters involved in its behavioral effect.
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- Intensive insulin therapy is effective for managing diabetes but can lead to dangerous hypoglycemia, primarily detected by the ventromedial hypothalamus (VMH) in the brain.
- The study aimed to explore the role of serotonin (5-HT) neurons in regulating the counter-regulatory response (CRR) to hypoglycemia.
- Results indicated that insulin increases activity in dorsal raphe 5-HT neurons and affects glucagon secretion, highlighting a significant role of the serotonin network in responding to insulin-induced low blood sugar levels.
Major depressive disorder (MDD) is a serious public health problem, as it is the most common psychiatric disorder worldwide. Antidepressant drugs increase adult hippocampal neurogenesis, which is required to induce some behavioral effects of antidepressants. Adult-born granule cells in the dentate gyrus (DG) and the glutamate receptors subunits 2 (GluN2B) subunit of N-methyl-D-aspartate (NMDA) ionotropic receptors play an important role in these effects.
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