Publications by authors named "J Le Guen"
Introduction: Pneumonia is one of the most common indications for antibiotic. Shortening the duration of antibiotic therapy should help reduce bacterial resistance. To date, three randomized control trials have shown non-inferiority of short courses of antibiotic therapy (3 days) compared with 7 days in non-severe pneumonia.
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- Researchers conducted a study on patients aged 70 and older to evaluate the occurrence of local complications from peripheral venous catheters, focusing on risk factors and their impact on patient outcomes.
- The study involved monitoring 322 patients in a French hospital, revealing an incidence rate of complications at 50.5 per 1000 catheter-days, with factors like dressing replacement and specific medications increasing the risk.
- Findings indicated that complications led to longer hospital stays, suggesting the need for careful clinical monitoring to improve patient care for this age group.
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- Percutaneous left atrial appendage closure is aimed at patients with atrial fibrillation who are at high risk for blood clots and bleeding, and this study evaluates its effectiveness and safety in a French medical center from 2014 to 2020.
- The study involved 207 patients, achieving a successful closure rate of 97.6%, while noting a decline in procedural complications over the years and a significant reduction in both thromboembolic and bleeding events during follow-up.
- The findings highlight the procedure's benefits and the importance of collaborative medical expertise to ensure successful outcomes in this high-risk patient population.*
Background: Although a growing number of very elderly patients with atrial fibrillation (AF), multiple conditions, and polypharmacy receive direct oral anticoagulants (DOACs), few studies specifically investigated both apixaban/rivaroxaban pharmacokinetics and pharmacodynamics in such patients.
Aims: To investigate: (1) DOAC concentration-time profiles; (2) thrombin generation (TG); and (3) clinical outcomes 6 months after inclusion in very elderly AF in-patients receiving rivaroxaban or apixaban.
Methods: Adage-NCT02464488 was an academic prospective exploratory multicenter study, enrolling AF in-patients aged ≥80 years, receiving DOAC for at least 4 days.
The relationship with death has evolved. Funeral rites are becoming less common, while deaths in hospital are more frequent. This societal evolution has led the hospital and the nursing staff to have to adapt and organize themselves to better support patients at the end of life and their families.
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