A bespoke water T-maze apparatus and protocol: an optimized, reliable, and repeatable method for screening learning, memory, and executive functioning in laboratory mice.

The Morris Water Maze (MWM) is the most commonly used assay for evaluating learning and memory in laboratory mice. Despite its widespread use, contemporary reviews have highlighted substantial methodological variation in experimental protocols and that the associated testing procedures are acutely (each trial) and chronically (testing across days) stressful; stress impairs attention, memory consolidation and the retrieval of learned information. Moreover, the interpretation of behavior within the MWM is often difficult because of wall hugging, non-spatial swim strategies, floating, and jumping off the escape platform.

Oral pre-exposure prophylaxis implementation in South Africa: a case study of USAID-supported programs.

Since the introduction of oral pre-exposure prophylaxis (PrEP) in 2016, countries have successfully scaled-up PrEP to populations at risk of HIV acquisition, including key populations, serodiscordant couples and pregnant women. Between 2016 and 2023, there were over 5.6 million oral PrEP initiations globally.

Determining If Post-Injury Financial Distress Was Preexisting or Injury-Induced: A Prospective Cohort Study of Patients with Lower-Extremity Trauma.

Background: Previous research has estimated that over one-half of patients with orthopaedic trauma experience financial distress after the injury. However, it is unknown what proportion of patients lived under financial distress before the injury and, therefore, the causal effect of the injury on financial distress. This study examined changes in financial distress after the injury and factors associated with new post-injury financial distress.

Long-term outcome following multimodality treatment in a cat with recurrent laryngeal adenocarcinoma.

A 9.5-year-old male neutered domestic short-haired cat received two courses of postoperative, definitive-intent conformal radiation therapy (RT) for recurrent laryngeal adenocarcinoma (LACA). Adjuvant RT was prescribed (16 × 3.

Reparations for African Enslavement in the U.S. and Black Survival Using the Panel Study of Income Dynamics.

Activists, policymakers, and scholars increasingly have advocated for reparations payments to Black Americans to redress the harms of enslavement and discriminatory practices that followed. This study examined the effects of a hypothetical monetary reparations intervention on all-cause premature and overall mortality among Black adults in the U.S.