Publications by authors named "J Langfort"

Article Synopsis
  • The study investigates the role of brain-derived neurotrophic factor (BDNF) and specific genetic variations (SNPs) in the early-onset of Parkinson's disease (PD), focusing on patients under 55 years old.
  • Researchers analyzed the genetic profiles of 163 PD patients and 91 healthy controls, revealing that individuals with the AG genotype of the BDNF gene have a threefold higher risk of developing early PD compared to those with the GG genotype.
  • The findings also showed that lower levels of serum BDNF were associated with the AG and AA genotypes, indicating that the Val66Met polymorphism in the BDNF gene contributes to lower blood BDNF levels and increased risk of early-onset
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This study explores the effects of normobaric hypoxia and intermittent hypoxic training (IHT) on the physiological condition of the cardiac muscle in swimmers. Hypoxia has been reported to elicit both beneficial and adverse changes in the cardiovascular system, but its impact on the myocardium during acute exercise and altitude/hypoxic training remains less understood. We aimed to determine how a single bout of intense interval exercise and a four-week period of high-intensity endurance training under normobaric hypoxia affect cardiac marker activity in swimmers.

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Article Synopsis
  • * A study involving male competitive cyclists assessed the effects of normobaric hypoxia on blood sphingolipid metabolism during graded exercise and a simulated time trial.
  • * Results showed that while submaximal exercise increased plasma dihydrosphingosine-1-phosphate (dhS1P), maximal exercise raised HDL-bound S1P levels, but hypoxia decreased post-exercise plasma S1P concentration overall.
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The aim of the study was to examine whether a single bout of exercise to volitional exhaustion, performed under moderate normobaric hypoxia (H), would affect psychomotor performance (PP) in differently trained athletes. For this purpose, ten strength-trained (S) athletes, ten endurance-trained (E) athletes and ten healthy men leading a sedentary lifestyle as a control (C) group performed voluntarily two graded exercise tests until volitional exhaustion (EVE) under normoxia (N) and H (FiO = 14.7%).

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Physical exercise involves increased neuronal activity of many brain structures, but 1H-MRS investigations on the effects of human brain glutamate (Glu) concentrations on acute exercise have been sparse. Previous studies consistently found increases in brain lactate (Lac) concentrations following graded exercise up to 85% of the predicted maximal heart rate. However, the reported effects on brain concentrations of glutamine and glutamate were not consistent.

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