Dynamic Control of Weight-Update Linearity in Magneto-Ionic Synapses.

Multifunctional hardware technologies for neuromorphic computing are essential for replicating the complexity of biological neural systems, thereby improving the performance of artificial synapses and neurons. Integrating ionic and spintronic technologies offers new degrees of freedom to modulate synaptic potentiation and depression, introducing novel magnetic functionalities alongside the established ionic analogue behavior. We demonstrate that magneto-ionic devices can perform as synaptic elements with dynamically tunable depression linearity controlled by an external magnetic field, a functionality reminiscent of neuromodulation in biological systems.

α-Synuclein Deletion Impairs Platelet Function: A Role for SNARE Complex Assembly.

Granule secretion is an essential platelet function that contributes not only to haemostasis but also to wound healing, inflammation, and atherosclerosis. Granule secretion from platelets is facilitated, at least in part, by Soluble N-ethylmaleimide-Sensitive Factor (NSF) Attachment Protein Receptor (SNARE) complex-mediated granule fusion. Although α-synuclein is a protein known to modulate the assembly of the SNARE complex in other cells, its role in platelet function remains poorly understood.

MS -Pushing the Limits for Biomolecular Mass Spectrometry.

Electrospray mass spectrometry has become indispensable in many disciplines including the classic "omics" techniques such as proteomics or lipidomics, as well as other life science applications in molecular, cellular, and structural biology. However, a limiting factor that often arises for the detection of biomolecular analytes is their poor ionization efficiency in the ion source. Here, we present an add-on device for the electrospray source, termed MS (MS Spectral Impurity Eliminator & Value Enhancer), which is placed between the electrospray needle and the cone of the mass spectrometer.

Synthesis of a multivalent α-1,2-mannobiose ligand for targeting C-type lectins.

The importance of lectins in biological processes such as pathogen recognition, cell adhesion, and cell recognition is well documented. C-Type lectins, which require calcium for binding, play an important role in the innate immune response by engaging carbohydrates presented as part of the human and pathogen glycocalyx. For example, lectins such as MBL, Dectin-2, langerin and DC-SIGN selectively recognize mannose rich (high-mannose) structures presented as part of the glycocalyx.