Publications by authors named "J Laiho"
The contribution of environmental factors to the pathogenesis of type 1 diabetes is considered substantial, but their identification has turned out to be challenging. Large prospective studies are crucial for reliable identification of environmental risk and protective factors. However, only few large prospective birth cohort studies have been carried out.
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- The nPOD-Virus group investigated the presence of viral RNA in pancreas and other tissues from organ donors, specifically focusing on type 1 diabetes samples, using advanced technologies and a large collection of pancreas samples.
- The study included pancreas, spleen, and other tissue samples from various donor groups, analyzing them with methods like RNA sequencing and RT-PCR to uncover viral infections.
- Results showed that enterovirus RNA was detected primarily in certain donor groups, with significantly higher rates in those with single islet autoantibodies compared to type 1 diabetes donors and control donors, indicating a possible link between enterovirus and autoimmunity in diabetes.
Coxsackievirus B (CVB) infection of pancreatic β cells is associated with β cell autoimmunity and type 1 diabetes. We investigated how CVB affects human β cells and anti-CVB T cell responses. β cells were efficiently infected by CVB in vitro, down-regulated human leukocyte antigen (HLA) class I, and presented few, selected HLA-bound viral peptides.
View Article and Find Full Text PDFAims/hypothesis: Infection with coxsackie B viruses (CVBs) can cause diseases ranging from mild common cold-type symptoms to severe life-threatening conditions. CVB infections are considered to be prime candidates for environmental triggers of type 1 diabetes. This, together with the significant disease burden of acute CVB infections and their association with chronic diseases other than diabetes, has prompted the development of human CVB vaccines.
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