Robust morris screening method (RMSM) for complex physiological models.

Background And Objectives: Morris screening sensitivity analysis (MSM) comes forth as the method needing the minimum number of model simulations to qualify the impact of input parameter variations on outputs of complex, nonlinear and overparametrized models. However, the reliability of MSM indices (mean and standard deviation) and the reproducibility of their results are rarely explored despite the input parameter tuning/identification needs. In fact, these models, such those used in medical applications as digital twins, often lie in this category and need efficient and robust tools to assess both sensitivity and reliability of the outputs to numerous input model parameters.

High-density Surface Electromyography as Biomarker of Muscle Aging.

Sarcopenia is a muscle disease with adverse changes that increase throughout the lifetime but with different chronological scales between individuals. Addressing "early muscle aging" is becoming a critical issue for prevention. Through the CHRONOS study, we demonstrated the ability of the high-density surface electromyography (HD-sEMG), a noninvasive, wireless, portable technology, to detect both healthy muscle aging and accelerated muscle aging related to a sedentary lifestyle, one of the risk factors of sarcopenia.

Statistical shape analysis of gravid uteri throughout pregnancy by a ray description technique.

In order to study the anatomical variability of the uterus induced by pregnancy, a parametrization of gravid uterine geometry based on principal component analysis (PCA) is proposed. Corresponding meshes used for PCA are created by a ray description technique applied to a reference mesh. A smoothed voxel-based methodology is applied to determine the reference mesh from a database of 11 real shapes produced by the FEMONUM project.

Multiscale Hill-type modeling of the mechanical muscle behavior driven by the neural drive in isometric conditions.

In this study, we present a new model describing the mechanical behavior of the skeletal muscle during isometric contraction. This model is based on a former Hill-inspired model detailing the electromechanical behavior of the muscle based on the Huxley formulation. However, in this new multiscale model the muscle is represented at the Motor Unit (MU) scale.