Publications by authors named "J Laffosse"
Background: The management of prosthetic joint infection usually consists of a combination of surgery and antimicrobial therapy. The appropriate duration of antimicrobial therapy for this indication remains unclear.
Methods: We performed an open-label, randomized, controlled, noninferiority trial to compare 6 weeks with 12 weeks of antibiotic therapy in patients with microbiologically confirmed prosthetic joint infection that had been managed with an appropriate surgical procedure.
Purpose: There is no consensus regarding systematic screening for infection in aseptic revision total hip arthroplasty (THA). The rationale for systematic intra-operative samples is to increase the sensitivity of latent infections detection, which may require specific treatment. However, the incidence of occult infection in revision THAs is not precisely known.
View Article and Find Full Text PDFA Multicentric, Open-Label, Randomized, Comparative Clinical Trial of Two Different Doses of Expanded hBM-MSCs Plus Biomaterial versus Iliac Crest Autograft, for Bone Healing in Nonunions after Long Bone Fractures: Study Protocol.
Stem Cells Int
February 2018
Article Synopsis
- ORTHOUNION is a randomized clinical trial comparing the effectiveness of autologous human bone marrow-derived stem cell (hBM-MSC) treatments versus iliac crest autograft (ICA) for improving bone healing in patients with nonunion fractures that have not healed for over nine months.
- The trial will involve 108 participants who will be divided into three groups: one receiving a low dose of hBM-MSCs, another receiving a high dose, and a control group receiving ICA, all monitored for one to two years.
- The main goal is to see if hBM-MSCs combined with biomaterials lead to better bone healing compared to ICA, with a secondary goal of determining if a lower dose (100
Periprosthetic shoulder infection (PSI) is rare but potentially devastating. The rate of PSI is increased in cases of revision procedures, reverse shoulder implants and co-morbidities. One specific type of PSI is the occurrence of low-grade infections caused by non-suppurative bacteria such as or .
View Article and Find Full Text PDFBackground: The goal of this study was to assess the efficacy of cryotherapy with dynamic intermittent compression (CDIC) in relieving postoperative pain, decreasing blood loss, and improving functional scores after revision total knee arthroplasty (rTKA).
Methods: We conducted a prospective case-control study (level of evidence: I) to evaluate the efficacy of CDIC on postoperative bleeding, pain, and functional outcomes after rTKA. Forty-three cases were included at a single institution and divided in 2 groups: a control group without CDIC (n = 19) and an experimental group with CDIC (n = 24).