Publications by authors named "J Lachter"
Introduction: Locally advanced unresectable pancreatic cancer (LAPC) has a dismal prognosis, with intratumoral therapies showing limited benefits. We assume that the dense stroma within these tumors hampers drug dispersion.
Aim: This study explores the efficacy of multisite intratumoral injections in improving a drug's distribution while minimizing its side effects.
Article Synopsis
- * In a study of 2552 high-risk individuals, 1% developed neoplastic progression to PC or high-grade dysplasia within an average follow-up of 29 months, often without prior detectable lesions.
- * Successful early detection was linked to the removal of cystic lesions and smaller lesions, highlighting the need for improved diagnostic tools to catch these issues sooner, as many cancers advanced before the next scheduled examination.
Background And Aims: Colorectal cancer is a leading cause of death. Colonoscopy is the criterion standard for detection and removal of precancerous lesions and has been shown to reduce mortality. The polyp miss rate during colonoscopies is 22% to 28%.
View Article and Find Full Text PDFBackground: Surveillance of individuals at high risk of pancreatic ductal adenocarcinoma (PDAC) and its precursors might lead to better outcomes. The aim of this study was to determine the prevalence and outcomes of PDAC and high-risk neoplastic precursor lesions among such patients participating in surveillance programmes.
Methods: A multicentre study was conducted through the International CAncer of the Pancreas Screening (CAPS) Consortium Registry to identify high-risk individuals who had undergone pancreatic resection or progressed to advanced PDAC while under surveillance.