Publications by authors named "J Labad"
Lymphocyte-derived and lipoprotein-derived inflammatory ratios as biomarkers in bipolar disorder type I: Characteristics, predictive values, and influence of current psychopharmacological treatments.
Psychoneuroendocrinology
January 2025
Purpose Of This Research: The purpose of this research was to investigate peripheral inflammation by analyzing lymphocyte and lipoprotein-derived inflammatory ratios in patients with bipolar disorder type I (BD-I) and healthy controls (HCs), considering mood stabilizer drug treatments, sex and clinical trajectories.
Methods: This was a cross-sectional case-control study of BD-I patients (n=252) and healthy controls (n=62). We investigated peripheral inflammation biomarkers through blood count values (CBCs), lipoproteins and a complex panel of inflammatory ratios, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), neutrophil-to-HDL ratio (NHR), monocyte-to-HDL ratio (MHR), platelet-to-HDL ratio (PHR) and lymphocyte-to-HDL ratio (LHR).
Article Synopsis
- Prenatal infections during pregnancy can lead to neurodevelopmental issues and psychiatric disorders, particularly through maternal immune activation (MIA) in animal models.
- In a study with Long-Evans rats, administration of the viral component polyI:C increased fear responses in male offspring when exposed to inescapable shocks and enhanced fear conditioning compared to females.
- The findings suggest that male offspring are more sensitive to the effects of MIA on fear responses, providing a model to investigate the neurobiological mechanisms of altered fear conditioning related to schizophrenia.
Corrigendum: Psychosocial stress moderates the relationship between cerebrospinal fluid lactate dehydrogenase and the duration of untreated psychosis in first-episode psychosis.
Front Psychiatry
May 2024
[This corrects the article DOI: 10.3389/fpsyt.2024.
View Article and Find Full Text PDFArticle Synopsis
- - Neuroinflammation and disruption of the blood-cerebrospinal fluid barrier may play significant roles in the development and symptom severity of schizophrenia-spectrum disorders (SSDs), according to a large meta-analysis of first-episode psychosis and recent onset psychotic disorder individuals.
- - Data from 531 individuals showed that while cerebrospinal fluid (CSF) alterations were present in 38.8% of cases, no overall significant link between CSF changes and symptom severity was found; however, males with such alterations had higher positive symptom scores.
- - The study emphasizes that disruption of the blood-cerebrospinal fluid barrier is common in early psychosis and suggests the importance of addressing this disruption along with sex-related differences