Publications by authors named "J LECLERCQ"
Strong antileishmanial and antitrypanosomal activities were highlighted for the crude methanolic extract (IC = 0.61 and 2.15 μg/mL, respectively) of Zanthoxylum zanthoxyloides (Lam.
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- - The study focuses on understanding how gene expression changes contribute to the developmental evolution of cavefish (Astyanax mexicanus) by comparing the transcriptomes of surface-dwelling and blind cave-adapted morphs.
- - It was found that around 20% of the transcriptome showed differential expression, and changes in gene expression were primarily driven by cis-regulatory alterations rather than coding sequence mutations.
- - Specifically, the research highlighted the role of the rx3 gene, noting that its expression levels are regulated in a cell-autonomous way, while its spatial domain size is influenced by signaling pathways, indicating a complex regulation of gene expression that leads to morphological differences in cavefish.
Objective: Alcohol minimum unit pricing (MUP) policies establish a floor price beneath which alcohol cannot be sold. The potential effectiveness of MUP policies for reducing alcohol-attributable deaths in the United States has not been quantitatively assessed. Therefore, this study estimated the effects of two hypothetical distilled spirits MUP policies on alcohol sales, consumption, and alcohol-attributable deaths in one state.
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- Amyloid fibrils usually consist of multiple copies of the same protein arranged in a specific structure, but recent studies show that different proteins can also co-aggregate to form mixed amyloid structures.
- Co-aggregation is significant because it affects the infectivity of amyloids and the mechanisms behind functional amyloids, prompting researchers to analyze its structural characteristics more closely.
- A new computational method has been developed to predict which amyloidogenic proteins can stack together, and this study included a dataset of known protein pairs to improve the algorithm, potentially aiding in identifying proteins that could trigger amyloidosis in humans.
A growing wealth of data suggest that reactive oxygen species (ROS) signalling might be crucial in conferring embryonic or adult stem cells their specific properties. However, how stem cells control ROS production and scavenging, and how ROS in turn contribute to stemness, remain poorly understood. Using the Xenopus retina as a model system, we first investigated the redox status of retinal stem cells (RSCs).
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