Publications by authors named "J LACOSTE"
Objectives: To study the national trends of anticoagulants, antiarrhythmic drugs (AADs), and expenditures in the civilian noninstitutionalized atrial fibrillation (AF) population.
Methods: The Medical Expenditure Panel Survey was queried from January 2016 to December 2021 to identify adults (age ≥18 years) with a diagnosis of AF utilizing the International Classification of Diseases, Tenth Revision, Clinical Modification code I48. Prevalence of anticoagulants (AAD) and its expenditure and AF expenditure across clinical settings in the United States were estimated.
Article Synopsis
- * A study using a human mutation library identified certain unstable mutations that predominantly rely on the ubiquitin proteasome system for degradation and found that the co-chaperones DNAJA1 and DNAJA2 interact significantly with one of the mutated proteins.
- * DNAJA2 plays a dual role: it stabilizes various normal proteins and specifically helps reduce the breakdown of some mutated proteins, highlighting how the protein quality control mechanisms adapt to handle misfolded proteins in the cytosol.
Article Synopsis
- * Using a capture-recapture method and data from various sources, researchers found 287 cases of drug use, predominantly among males, with crack cocaine being the most commonly used substance.
- * The estimated prevalence of problematic drug use in Martinique is 1.936 per 380,863 inhabitants, translating to 5.0 per thousand overall and 7.7 per thousand among those aged 15-64 years.
Article Synopsis
- Aspirin (ASA) has been the leading antiplatelet medication since 1897 for preventing and treating cardiovascular diseases, prompting a study on its trends and costs in the USA from 2000 to 2021.
- The research found that ASA users increased from 2.9 million to 6.6 million, with a notable rise in usage among women and African Americans, while low-dose use gained popularity and high-dose use decreased.
- Approximately 60 million USD was spent annually on ASA, with half of its users having no known cardiovascular disease, especially among individuals aged 50-69 and those over 70, indicating a need for further research on the implications of this increasing usage.