Publications by authors named "J L van der Plas"
Background: Intranasal administration of respiratory vaccines offers many advantages such as eliciting both systemic and mucosal immunity at the point of viral entry. Immunogenicity of intranasal vaccination can be improved through the use of adjuvants. Bacteria-like particles derived fromLactococcus lactishave the potential to serve as a vaccine adjuvant.
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- The study aimed to compare the effects of two target ranges for peripheral oxygen saturation (SpO) on hypoxic and hyperoxic episodes in infants receiving respiratory support.
- Conducted in a neonatal unit in the Netherlands, the randomized cross-over study involved 27 infants, assessing their oxygen levels while using the OxyGenie controller.
- Results indicated that while a higher SpO target range (92%-96%) reduced the frequency of hypoxic episodes, it also increased the frequency of hyperoxic episodes, suggesting the potential of automated oxygen titration in neonatal care.
A paradigm shift in research culture is required to ease perceived tensions between autistic people and the biomedical research community. As a group of autistic and non-autistic scientists and stakeholders, we contend that through participatory research, we can reject a deficit-based conceptualization of autism while building a shared vision for a neurodiversity-affirmative biomedical research paradigm.
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- Cabamiquine is a new antimalarial drug that targets Plasmodium falciparum translation elongation factor 2 and was tested for its ability to prevent malaria in healthy, malaria-naive volunteers through a phase 1b clinical trial in the Netherlands.
- The study involved 39 participants divided into cohorts, receiving different doses of cabamiquine or a placebo after being inoculated with malaria sporozoites, with various outcomes measured including the development of parasitaemia and safety profiles.
- Results from the trial are still being evaluated to determine the effectiveness and safety of cabamiquine as a potential chemoprophylactic treatment for malaria.
Introduction: Diffusion-weighted imaging (DWI) as part of multiparametric magnetic resonance imaging (mpMRI) is an important sequence for the detection of prostate cancer (PCa). The objective of this retrospective analysis was to evaluate changes in apparent diffusion coefficient (ADC) measurements in biopsy-proven PCa undergoing TULSA-PRO (MR-guided transurethral ultrasound ablation of the prostate) at 3.0 T after 1, 3, and 6-12 months posttreatment.
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