Involvement of the disulfidptosis-related immune checkpoint gene, CD276, in glioblastoma malignant phenotype and poor prognosis.

Background: Immunotherapy has promise for glioblastoma multiforme (GBM) treatment and disulfidptosis, a form of cell death involving disintegration of the actin cytoskeleton, is a potential target. The aim of the current study was to identify genes associated with disulfidptosis-related immune checkpoints in GBM and to analyze connections with malignancy.

Methods: Two expression matrices from The Cancer Genome Atlas-Genotype Tissue Expression (TCGA-GTEx) and Chinese Glioma Genome Atlas (CGGA) cyber public data were utilized to analyze differentially expressed genes (DEGs) in GBM and interaction networks for DEG-coded proteins constructed with protein-protein interaction network analysis.

Deucravacitinib in plaque psoriasis: Four-year safety and efficacy results from the Phase 3 POETYK PSO-1, PSO-2 and long-term extension trials.

Background: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 (TYK2) inhibitor, is approved in multiple countries for treatment of adults with moderate to severe plaque psoriasis who are candidates for systemic therapy.

Objectives: To evaluate the safety and efficacy of deucravacitinib through 4 years in the Phase 3 POETYK PSO-1, PSO-2 and long-term extension (LTE) trials in psoriasis.

Methods: PSO-1 and PSO-2 (parent trials) randomized patients 1:2:1 to oral placebo, deucravacitinib 6 mg once daily (QD) or apremilast 30 mg twice daily.

Measurement of the Branching Fraction Ratios R(D^{+}) and R(D^{*+}) Using Muonic τ Decays.

The branching fraction ratios of B[over ¯]^{0}→D^{+}τ^{-}ν[over ¯]_{τ} and B[over ¯]^{0}→D^{*+}τ^{-}ν[over ¯]_{τ} decays are measured with respect to their muonic counterparts, using a data sample corresponding to an integrated luminosity of 2.0  fb^{-1} collected by the LHCb experiment in proton-proton collisions at sqrt[s]=13  TeV. The reconstructed final states are formed by combining D^{+} mesons with τ^{-}→μ^{-}ν[over ¯]_{μ}ν_{τ} candidates, where the D^{+} is reconstructed via the D^{+}→K^{-}π^{+}π^{+} decay.