Cardiopulmonary bypass with deep hypothermic circulatory arrest results in organ-specific transcriptomic responses in pediatric swine.

The organ-level molecular response to cardiac surgery with cardiopulmonary bypass (CPB) remains inadequately understood and may be heterogeneous. Here, we measured organ-specific gene expression in a piglet model of CPB with deep hypothermic circulatory arrest (DHCA). Infant piglets underwent peripheral CPB with 75min of DHCA and 6h of critical care after separation from CPB.

The CoREST-complex regulates MYC stability and promotes post-transcriptional mRNA splicing in melanoma.

Unlabelled: The maturation of RNA is mediated by the coordinated actions of RNA-binding proteins through post-transcriptional pre-mRNA processing. This process is a central regulatory mechanism for gene expression and plays a crucial role in the development of complex biological systems. MYC directly upregulates transcription of genes encoding the core components of pre-mRNA splicing machinery.

Phenomenology of Many-Body Localization in Bond-Disordered Spin Chains.

Many-body localization (MBL) hinders the thermalization of quantum many-body systems in the presence of strong disorder. In this Letter, we study the MBL regime in bond-disordered spin-1/2 XXZ spin chain, finding the multimodal distribution of entanglement entropy in eigenstates, sub-Poissonian level statistics, and revealing a relation between operators and initial states required for examining the breakdown of thermalization in the time evolution of the system. We employ a real space renormalization group scheme to identify these phenomenological features of the MBL regime that extend beyond the standard picture of local integrals of motion relevant for systems with disorder coupled to on-site operators.

Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study.

This nested case-control study identified broad dysregulation of the circulating proteome in neonates receiving postoperative extracorporeal membrane oxygenation support after congenital heart disease surgery, including differential responses in those not surviving to hospital discharge. Tissue hypoxia and mitochondrial-associated proteins may represent novel candidate biomarkers for poor extracorporeal membrane oxygenation outcomes.