RNA nanotherapeutics for hepatocellular carcinoma treatment.

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, particularly due to the limited effectiveness of current therapeutic options for advanced-stage disease. The efficacy of traditional treatments is often compromised by the intricate liver microenvironment and the inherent heterogeneity. RNA-based therapeutics offer a promising alternative, utilizing the innovative approach of targeting aberrant molecular pathways and modulating the tumor microenvironment.

Factors influencing preformed metal crowns and prefabricated zirconia crowns.

Backgound: Preformed metal crowns (PMCs) and zirconia crowns (ZCs) are commonly used for the treatment of primary molar caries. However, there have been no reports on factors influencing parental awareness, willingness to use these treatments, and the associated discomfort after crown placement in children.This study is the first to report factors influencing preformed crowns, providing a reference for the prevention and treatment of deciduous carious teeth.

Correlation between METTL3 overexpression and F-FDG uptake in patients with soft tissue sarcoma.

Background: N6-methyladenosine (m6A) methylation plays a key role in tumor progression. However, the significance of methyltransferase-like 3 (METTL3) in biological processes of soft tissue sarcoma (STS) patients, and the relationship between METTL3 and STS are unclear.

Methods: The expression of METTL3 in STS and its relationship with patient prognosis were determined from database analyses.

Therapeutic Potential of Cinnamon Oil: Chemical Composition, Pharmacological Actions, and Applications.

Cinnamon oil, an essential oil extracted from plants of the genus Cinnamomum, has been highly valued in ancient Chinese texts for its medicinal properties. This review summarizes the chemical composition, pharmacological actions, and various applications of cinnamon oil, highlighting its potential in medical and industrial fields. By systematically searching and evaluating studies from major scientific databases including Web of Science, PubMed, and ScienceDirect, we provide a comprehensive analysis of the therapeutic potential of cinnamon oil.

Study on the Dynamic Fracture Properties of Defective Basalt Fiber Concrete Materials Under a Freeze-Thaw Environment.

This study examines the crack resistance of basalt-fiber-reinforced concrete (BFRC) materials subjected to freeze-thaw cycles (FTCs). We utilized a φ50 mm Split Hopkinson Pressure Bar (SHPB) apparatus alongside numerical simulations to carry out impact compression tests at a velocity of 5 m/s on BFRC specimens that experienced 0, 10, 20, and 30 FTCs. Additionally, we investigated the effects of basalt fiber (BF) orientation position and length on stress intensity factors.