Publications by authors named "J L William"
Unlabelled: Periodontitis (PD) is a polymicrobial dysbiotic immuno-inflammatory disease. Toll-like receptors (TLRs) are present on gingival epithelial cells and recognize pathogen-associated molecular patterns (PAMPs) on pathogenic bacteria, induce the secretion of proinflammatory cytokines, and initiate innate and adaptive antigen-specific immune responses to eradicate the invading microbes. Since PD is a chronic inflammatory disease, TLR2/TLR4 plays a vital role in disease pathogenesis and maintaining the periodontium during health.
View Article and Find Full Text PDFArticle Synopsis
- Pediatric renal cell carcinoma (pRCC) is a rare, aggressive cancer in children with lower survival rates compared to other pediatric cancers, influenced by factors like sex, race, ethnicity, age, and socio-economic status.
- A retrospective study analyzed 174 pRCC cases from 1973 to 2015 to understand survival rates, identifying significant disparities, such as black/AA children being nearly three times more likely to die from the disease than white children.
- The study highlights the need for further research into socio-economic and demographic factors affecting pRCC outcomes, as well as exploring insufficiently studied determinants like area of residence.
Article Synopsis
- In-center and home dialysis have improved survival rates for patients with end-stage kidney disease and can lead to kidney transplants.
- Kidney health care providers need to be aware of the potential complications that can arise from these dialysis treatments.
- Effective care for dialysis patients requires knowledge beyond just nephrology, including understanding cardiovascular, infectious, and musculoskeletal issues.
The Nephrology Boards and Certification Exams: A Worldwide Focus on Excellence.
Adv Kidney Dis Health
November 2024
Article Synopsis
- * The KDOQI Work Group generally agrees with KDIGO's suggestions for CKD evaluation, management options, and the use of new medications such as SGLT2 inhibitors for various CKD types, particularly in patients with diabetes.
- * The guidelines stress team-based care as essential in addressing CKD challenges, and the work group has identified barriers and opportunities for implementing these new recommendations while continuing research on early CKD detection and treatment.