Publications by authors named "J L Waaijer"
Elderly with late-onset recurrent respiratory tract infections (RRTI) often have specific anti-polysaccharide antibody deficiency (SPAD). We hypothesized that late-onset RRTI is caused by mild immunodeficiencies, such as SPAD, that remain hidden through adult life. We analyzed seventeen elderly RRTI patients and matched controls.
View Article and Find Full Text PDFImpact of serotherapy on immune reconstitution and survival outcomes after stem cell transplantations in children: thymoglobulin versus alemtuzumab.
Biol Blood Marrow Transplant
March 2015
Article Synopsis
- Allogeneic hematopoietic stem cell transplantation (HSCT) outcomes are influenced by how quickly the immune system recovers, with a study comparing antithymocyte globulin (ATG) and alemtuzumab in 148 pediatric patients.
- Alemtuzumab significantly delayed the recovery of key immune cells (CD3(+) T cells, CD4(+) T cells, CD8(+) T cells, and natural killer cells) compared to ATG, leading to lower donor chimerism and increased disease relapse risk.
- Patients treated with alemtuzumab experienced lower overall survival and event-free survival rates, prompting a recommendation for further analysis to optimize HSCT conditioning regimens based on drug exposure.
Reconstitution of lymphocyte subpopulations after paediatric bone marrow transplantation.
Bone Marrow Transplant
February 2000
We prospectively studied the reconstitution of lymphocyte subpopulations in a group of 22 children, who survived disease-free at least 6 months after allogeneic BMT for a haematological malignancy. Absolute counts of total lymphocytes, B lymphocytes, T lymphocytes, and CD4+ helper T lymphocytes reached the 5th percentile (p5) of age-matched reference values within 6 months after BMT in 15, 17, 7 and 2 patients, respectively. In particular, CD4+ helper T lymphocyte reconstitution was very slow.
View Article and Find Full Text PDFFetal B lymphocytes in mice and humans use a limited number of the available VH gene segments. Mouse fetal B cells primarily utilize 3' VH elements, suggesting that the localization of these elements determines their rearrangement frequency. The previously reported non-random usage of human VH genes has been more difficult to explain.
View Article and Find Full Text PDFWe found an unusual fc gamma receptor IIIa (CD16) phenotype on the natural killer (NK) cells of a 3-year-old boy, who suffered from recurrent viral respiratory tract infections since birth. He also had severe clinical problems after Bacille Calmette-Geérin (BCG) vaccination and following Epstein-Barr virus and Varicella Zoster virus infections. His peripheral blood lymphocytes contained a normal percentage and absolute number of CD3-CD7+ cells, which were positively stained with the CD16 monoclonal antibodies (MoAbs) 3G8 and CLBFcRgran1, but did marginally stain with the CD16 MoAb Lau11c/B73.
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