Multi-cohort analysis identifying core ocular surface microbiome and bacterial alterations in eye diseases.

Purpose: Inconsistency exists among reported studies on the composition of human ocular surface microbiome (OSM). The roles of OSM in ocular diseases remain uncertain. In this study, we aimed to determine the composition of OSM and to evaluate its potential roles and functions from multiple cohorts.

Multitargeting Pt(IV) Derivatives of Cisplatin or Oxaliplatin Inhibit Tumor Growth in Mice without Inducing Neuropathic Pain.

Cisplatin and oxaliplatin are Pt(II) anticancer agents that are used to treat several cancers, usually in combination with other drugs. Their efficacy is diminished by dose-limiting peripheral neuropathy (PN) that affects ∼70% of patients. PN is caused by selective accumulation of the platinum drugs in the dorsal root ganglia (DRG), which overexpress transporters for cisplatin and oxaliplatin.

Effectiveness of community-based participatory research (CBPR) interventions on mental health outcomes: A systematic review.

Community-based participatory research (CBPR) promotes the significant involvement of community members in research, which helps increase the effectiveness of specific interventions for community members. However, no reviews have investigated the effectiveness of CBPR interventions in mental health outcomes nor the adherence level to CBPR principles. Therefore, the objectives of the current study were to (1) examine the effectiveness of CBPR interventions on mental health outcomes and (2) assess the overall adherence to CBPR principles in existing mental health research.