Publications by authors named "J L Vacek"
Article Synopsis
- Molecules with spiral geometry, like DNA and proteins, are common in nature and serve as a basis for exploring helicenes, which are carbon-rich structures with unique optical and chiral properties.
- Helicienes are gaining traction in biomedicine for their applications in cell imaging, drug delivery systems, protective coatings for implants, biosensors, and drug discovery due to their ability to interact with biomolecules.
- The review highlights recent advancements in helicene derivatives that improve luminescence and photochemical properties, emphasizing their significance in enhancing bio-imaging and diagnostics in biomedical technology.
Cannabidiol (CBD) is a phytocannabinoid from Cannabis sativa L., in which there is currently growing interest for medicinal use. Here, we focused on the safety and pharmacokinetics of a CBD-rich (77 %, w/w) full-spectrum hemp extract in male and female rats.
View Article and Find Full Text PDFThe binding free energy of hydrogen-bonded complexes is generally inversely proportional to the solvent dielectric constant. This occurs because the solvent-accessible surface area of the complex is always smaller than that of the individual subsystems, leading to a reduction in solvation energy. The present study explores the potential for stabilizing hydrogen-bonded complexes in a solvent with higher polarity.
View Article and Find Full Text PDFLEAP! Rx: A randomized trial of a pragmatic approach to lifestyle medicine.
Alzheimers Dement
December 2024
Article Synopsis
- Researchers created a year-long exercise program called LEAP! Rx to help prevent Alzheimer's disease and tested it on 219 people.
- The program combined exercise with education about brain health and showed that participants who exercised regularly improved their fitness.
- Results suggest that doctors can help connect patients to community exercise programs, which may lead to better overall health and help reduce the risk of Alzheimer's.
Objectives: Excessive screen use in early school age is associated with worsened health habits and negative child development in later age. We aimed to assess the time spent on modern and traditional screen-based devices and examine its associations with socio-demographic characteristics.
Methods: This population-based cross-sectional observation study was conducted in Czechia, Slovakia and Finland between April and June 2021.