Publications by authors named "J L Treur"
Article Synopsis
- Sudden cardiac death significantly impacts the life expectancy of individuals with schizophrenia, possibly linked to arrhythmic disorders, although the exact relationship remains unclear.
- The study aimed to explore genetic connections and possible causal influences between schizophrenia and various heart-related conditions, utilizing extensive genetic data from large-scale studies.
- Findings revealed minimal global genetic correlation, but specific genetic regions showed strong links, suggesting that schizophrenia risk may increase the likelihood of developing certain arrhythmias like Brugada syndrome and affect heart rate during activities.
Aims: At the basis of many important research questions is causality - does X causally impact Y? For behavioural and psychiatric traits, answering such questions can be particularly challenging, as they are highly complex and multifactorial. 'Triangulation' refers to prospectively choosing, conducting and integrating several methods to investigate a specific causal question. If different methods, with different sources of bias, all indicate a causal effect, the finding is much less likely to be spurious.
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- - MDD and CVD commonly occur together, leading to higher health risks, and they share many genetic risk factors, with notable genetic overlaps found in specific brain regions like the thalamus.
- - The research identified seven genetic loci linked to both disorders and highlighted that factors like inflammation and lifestyle contribute to the shared risk between MDD and atherosclerotic CVD.
- - The findings suggest that genetic predisposition to MDD increases the risk of CVD, while the reverse is less evident, indicating a specific immunometabolic subtype of MDD that may be targeted for better prevention of CVD.
Article Synopsis
- * A review of 391 papers led to a detailed analysis of 277 MR studies focused on arrhythmia and cardiovascular traits, identifying several risk factors for AF, including high systolic blood pressure and elevated cardiac troponin I levels.
- * As genetic data becomes more available, the significance of MR increases, and combining it with other research methods can strengthen the reliability of conclusions drawn from these studies.
Article Synopsis
- Major depressive disorder (MDD) and cardiovascular disease (CVD) often occur together, leading to increased health issues and mortality rates.
- A study discovered that many genetic risk factors for CVD overlap with those for MDD, indicating a shared biological basis, particularly involving specific brain regions and cell types.
- The findings suggest that genetic predisposition to MDD can increase the risk of developing CVD, while lifestyle and metabolic factors also play significant roles, potentially creating an immunometabolic subtype of MDD more closely linked with CVD.