Systematic design and functionalisation of amorphous zirconium metal-organic frameworks.

Controlling the structure and functionality of crystalline metal-organic frameworks (MOFs) using molecular building units and post-synthetic functionalisation presents challenges when extending this approach to their amorphous counterparts (aMOFs). Here, we present a new bottom-up approach for synthesising a series of Zr-based aMOFs, which involves linking metal-organic clusters with specific ligands to regulate local connectivity. In addition, we overcome the limitations of post-synthetic modifications in amorphous systems, demonstrating that homogeneous functionalisation is achievable even without regular internal voids.

Imidazolium-Containing Hybrid Organic-Inorganic Materials for the Conversion of CO: Unveiling the Key Role of the Ionic Template.

A straightforward synthesis of a series of hybrid organic-inorganic materials (HOIMs) containing imidazolium moieties was achieved. The preparation of the imidazolium acetate precursor was performed in a single-step procedure using the Debus-Radziszewski reaction. The as-synthesized alkoxysilane was employed in combination with tetraethyl orthosilicate to generate an HOIM presenting a high specific surface area.

Genomic ALK alterations in primary and relapsed neuroblastoma.

Background: Genomic alterations of the anaplastic lymphoma kinase gene (ALK) occur recurrently in neuroblastoma, a pediatric malignancy of the sympathetic nervous system. However, information on their development over time has remained sparse.

Methods: ALK alterations were assessed in neuroblastomas at diagnosis and/or relapse from a total of 943 patients, covering all stages of disease.

Neuroblastoma Risk Assessment and Treatment Stratification with Hybrid Capture-Based Panel Sequencing.

For many years, the risk-based therapy stratification of children with neuroblastoma has relied on clinical and molecular covariates. In recent years, genome analysis has revealed further alterations defining risk, tumor biology, and therapeutic targets. The implementation of a robust and scalable method for analyzing traditional and new molecular markers in routine diagnostics is an urgent clinical need.