Publications by authors named "J L Semple"
Background: To meaningfully understand outcomes of gender-affirming care, patient-reported outcome measures (PROMs) that are grounded in what matters to individuals seeking care are urgently needed. The objective of this study was to develop a comprehensive PROM to assess outcomes of gender-affirming care in clinical practice, research, and quality initiatives (the GENDER-Q).
Methods: Internationally established guidelines for PROM development were used to create a field test version of the GENDER-Q.
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by an isolated thrombocytopenia and variable phenotype as some patients suffer no bleeding whilst others have bleeding from mild to severe, which may be fatal. This variability probably reflects the disease's complex pathophysiology; a dysregulated hyperreactive immune effector cell response involving the entire adaptive immune system (e.g.
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- Hematological diseases negatively impact the retina, leading to reduced retinal capillaries and visual function decline, potentially resulting in permanent vision loss.
- The study explores the effects of different blood disorders on retinal microvascular health using optical coherence tomography angiography (OCTA), revealing significant reductions in vessel density and changes in the avascular zone compared to healthy eyes.
- Patients with erythrocyte disorders had notable issues with linear and perfusion vessel density, while those with lymphocytic disorders displayed more significant changes in the foveal avascular zone, suggesting OCTA's potential in assessing and monitoring these blood-related visual impairments.
Background: CpG oligonucleotides (ODNs) are synthetic single-stranded DNA sequences that act as immunostimulants. They have been increasingly used to treat several cancers; however, thrombocytopenia is a potential recognized side effect of some sequences.
Objectives: We tested the ability of 2 CpG ODNs (ODN 2395 and ISIS 120704) to induce thrombocytopenia when administered to BALB/c mice and determined mechanisms associated with thrombocytopenia.