Publications by authors named "J L Segal"
While corticosteroids have led to significant reduction in ASUC mortality over the last few decades, they are associated with significant side effects and up to 30% of patients have steroid refractory ASUC, which means we require safer and better therapies for patients with ASUC. Several salvage therapies have been proposed in guidelines; however, we lack high quality head-to-head randomised controlled trials to assess effectiveness and safety of these agents. Furthermore, the role of newer novel agents in ASUC management is unclear.
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- The study evaluated the use of continuous video-electroencephalography (cEEG) to detect seizures in infants and children in a cardiovascular intensive care unit (CVICU), emphasizing symptoms and risk factors that led to cEEG evaluations.
- Among 605 cEEGs performed over 38 months, seizures were found in 9% of cases, with a significantly higher detection rate (30%) when both vital sign and non-vital sign symptoms were present, while isolated vital sign changes did not yield any seizures.
- The results indicated that certain symptoms (like gaze deviation and abnormal limb movements) and risk factors (like preexisting epilepsy and recent neuroscience surgeries) were linked to a higher likelihood of seizure detection, highlighting
Background/aims: Upadacitinib is a novel selective Janus kinase inhibitor approved for use in ulcerative colitis. Clinical trials had rigorous criteria and excluded many patient subgroups. Given limited real-world effectiveness data, we examined outcomes of patients treated with upadacitinib for ulcerative colitis in a real-world population.
View Article and Find Full Text PDFBackground: The COVID-19 pandemic resulted in the enactment of substantial public health measures aimed at reducing the transmission of respiratory viruses. The impact of these measures on gastrointestinal (GI) infections remains unexplored.
Aims: To determine whether there was a change in the number of patients presenting to The Royal Melbourne Hospital with GI infections during the COVID-19 pandemic compared to the year prior.