Publications by authors named "J L Seet"
This study investigates CD151, a protein linked to cancer progression, in non-small cell lung cancer (NSCLC) patients without epidermal growth factor receptor (EGFR) mutations. These patients often have limited treatment options. The study used retrospective analysis to examine 157 adenocarcinoma biopsy specimens and 199 patient cases from The Cancer Genome Atlas, correlating CD151 expression with patient survival.
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- A new DNA-barcoding technique has been developed to effectively map complex interactions between proteins within cells, capturing both pairwise and higher-order interactions.
- This method uses barcoded DNA strands attached to antibodies to link and analyze the interactions within 3D protein complexes.
- Research has shown that cancer cells have more diverse and abundant protein interactions than normal cells, with specific higher-order interactions linked to the aggressiveness of breast cancer subtypes.
In a mouse model of influenza pneumonia, we previously documented that proliferating alveolar type II (AT2) cells are the major stem cells involved in early lung recovery. Profiling of microRNAs revealed significant dysregulation of specific ones, including miR-21 and miR-99a. Moreover, miR-145 is known to exhibit antagonism to miR-21.
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