Publications by authors named "J L Schulman"
Article Synopsis
- - The STING pathway plays a crucial role in activating anti-tumor immunity, leading to interest in developing STING agonists for cancer treatment, but their effectiveness is limited by drug delivery issues.
- - Researchers created a new drug delivery system called SAPCon that combines a STING-activating prodrug with a polymer to enhance the drug's circulation and ensure it accumulates in tumors effectively.
- - Testing showed that SAPCon significantly boosts immune responses in tumors, leading to slower tumor growth and better survival rates in breast cancer models, thereby highlighting its potential as a powerful tool in cancer immunotherapy.
Article Synopsis
- This study investigated how common irritability is among U.S. adults and its relationship with major depressive and anxiety symptoms through an online survey involving over 42,000 participants.
- Results showed that women, younger individuals, those with lower education levels, and lower household incomes reported higher irritability scores.
- The findings also revealed a concerning link between increased irritability and suicidal thoughts, highlighting the need for further exploration of irritability's effects on mental health outside of immediate mood disorders.
The original article was published on February 15, 2024 and corrected on April 15, 2024.The revised version of the article corrects Figure 2. The changes appear in the revised online PDF copy of this article.
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