The Effects of Curodont Application on Human Gingival Fibroblasts.

To evaluate the cytotoxicity of Curodont (an alternative tooth varnish that promotes remineralization of incipient lesions using a self-assembling peptide P11-4) on soft tissue concerning gingival fibroblasts (GF) and assess survivability, proliferation, and attachment compared to silver diammine fluoride (SDF) and fluoride varnish (FV) as controls. Assessment of cell proliferation, survivability, and attachment was accomplished by studying the effects of varying concentrations of Curodont on gingival fibroblasts. Proliferation, survivability, and attachment were measured using Calcein-AM (a fluorescent dye that labels only living cells) via a microplate reader.

Measurements of Lung Size in Ultrasound and Magnetic Resonance Imaging in Congenital Diaphragmatic Hernia - A Comparison of Prenatal Imaging Techniques.

To investigate the correlation between different prenatal imaging techniques in congenital diaphragmatic hernia (CDH) and their prognostic value.209 fetuses with CDH were enrolled in this retrospective cohort study. The prenatal ultrasound-based and MRI-based (MRI: magnetic resonance imaging) observed-to-expected lung-to-head ratio (o/e-LHR) and MRI-based relative fetal lung volume (rFLV) were evaluated and compared.

The Influence of Concussion History and Progressively Increasing Cognitive Load on Jump Landing and Cutting Reaction Time, Biomechanics, and Task Demands.

Context:There is a 2-4x increased risk for musculoskeletal injury after concussion. A potential reason for the increased risk is aberrant biomechanics. The majority of prior research has focused on single-task biomechanics, but dual-task biomechanics may better represent athletic competition.

Immersive Analytics as a Support Medium for Data-driven Monitoring in Hydropower.

Hydropower turbines are large-scale equipment essential to sustainable energy supply chains, and engineers have few opportunities to examine their internal structure. Our Immersive Analytics (IA) application is part of a research project that combines and compares simulated water turbine flows and sensor-measured data, looking for data-driven predictions of the lifetime of the mechanical parts of hydroelectric power plants. Our prototype combines spatial and abstract data in an immersive environment in which the user can navigate through a full-scale model of a water turbine, view simulated water flows of three different energy supply conditions, and visualize and interact with sensor-collected data situated at the reference position of the sensors in the actual turbine.

Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility.

The co-occurrence of autism and gastrointestinal distress is well-established, yet the molecular underpinnings remain unknown. The identification of high-confidence, large-effect autism genes offers the opportunity to identify convergent, underlying biology by studying these genes in the context of the gastrointestinal system. Here we show that the expression of these genes is enriched in human prenatal gut neurons and their migratory progenitors, suggesting that the development and/or function of these neurons may be disrupted by autism-associated genetic variants, leading to gastrointestinal dysfunction.