Publications by authors named "J L Schiefer"
Article Synopsis
- This study examined postoperative pain management practices in women undergoing hysterectomy in Austria and Canada, focusing on opioid prescribing differences amid the opioid epidemic.
- It found that while total morphine equivalent doses (MED) were similar across both countries, Austria administered higher MED during surgery but significantly lower MED within the first 24 hours post-op compared to Canada.
- The findings suggest cultural attitudes towards pain management heavily influence prescribing practices, as evidenced by the stark contrast in discharge opioid prescriptions (98.5% in Canada vs. 0% in Austria), highlighting the need for further research in this area.
: Postoperative monitoring, following free flap surgery, plays a crucial role in ensuring the survival of the flap. However, in microsurgery, not only the immediate postoperative monitoring period but also the choice of the right time for secondary surgeries is crucial for the free flap survival. There is no clear consensus concerning the right choice of timing for secondary surgery.
View Article and Find Full Text PDFHigh-Intensity Blue Light (450-460 nm) Phototherapy for -Infected Wounds.
Photobiomodul Photomed Laser Surg
May 2024
Nosocomial wound infection with (PA) is a serious complication often responsible for the septic mortality of burn patients. High-intensity antimicrobial blue light (aBL) treatment may represent an alternative therapy for PA infections and will be investigated in this study. Antibacterial effects of a light-emitting diode array (450-460 nm; 300 mW/cm; 15/30 min; 270/540 J/cm) against PA were determined by suspension assay, biofilm assay, and a human skin wound model and compared with 15-min topically applied 3% citric acid (CA) and wound irrigation solution (Prontosan; PRT).
View Article and Find Full Text PDFHigh-Intensity Blue Light (450-460 nm) Phototherapy for -Infected Wounds.
Photobiomodul Photomed Laser Surg
May 2024
Nosocomial wound infection with (PA) is a serious complication often responsible for septic mortality of burn patients. High-intensity antimicrobial blue light (aBL) treatment may represent an alternative therapy for PA infections. Antibacterial effects of an light-emitting diode (LED) array (450-460 nm; 300 mW/cm; 15/30 min; 270/540J/cm) against PA were determined by suspension assay, biofilm assay, and a human skin wound model and compared with 15-min topically applied 3% citric acid (CA) and wound irrigation solution (Prontosan; PRT).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the cellular mechanisms behind heat-induced cell death in human fibroblasts, focusing on how extreme temperatures affect these cells over time.
- Researchers found that heating fibroblasts caused about 50% cell death, with a delayed response that peaked around five hours post-exposure, challenging the idea of traditional caspase-mediated apoptosis.
- Instead, the findings suggest a different death mechanism resembling Parthanatos, characterized by increased PARP1 protein levels and translocation of specific factors into the nucleus, indicating a unique response to heat stress rather than typical apoptotic processes.