Urinary elimination of erythropoietin in patients under treatment with cytostatics drugs.

Reductions in the hemoglobin (Hb) mass are followed by increases in the level of plasma erythropoietin (EPO) concentrations which are directly proportional to the level of the hormone required to bring the hemoglobin values back to normalcy. Hypoplastic anemias (AHC) on the other hand, are accompanied by significantly larger increases in the erythropoietin concentration. In this study we have measured the relationship between the severity of the anemia and the levels of erythropoietin elimination in the urine patients (EpoU) under treatment with cytostatic drugs.

A new approach to the etiopathogenesis of AIDS.

This hypothesis proposes as an explanation for the origin of the Acquired Immuno-Deficiency Syndrome (AIDS), the homosexual transmission of spermatozoons. The male gamete may possess a depressing action on the immuno-competence of the egg aimed to prevent the rejection of the spermatozoon material. The female organism may be able to inactivate this action, an ability that might be absent in the male organism.

[Ability of the Fe-transferring complex to transfer Fe to reticulocytes in nutritional anemia].

Using an in vitro technique the ability of the Fe/Transferrin complex in the serum of calories and proteins in chronically deprived adult males was investigated. The study included the behavior of the same function in the sera of other types of anemias. A significant reduction of the Fe donating capacity was found in the sera of patients suffering from nutritional anemia (NA), whereas this change was absent in the sera of other type of anemias.

Relationship between erythropoietic rate and iron donating capacity of the Fe/transferrin complex in mouse.

The transfer of iron from the Fe/transferrin complex to the erythroid cells was studied in in vitro system in mice in which a drastic and opposite change in their erythropoietic activity was produced by bleeding or actinomycin D administration. A reduction of iron donation in the serum of bled animals was found, whereas the aplastic condition induce in the donors of the serum by actinomycin D did not produce any change in the transfer process. It was also found that in spite of the normalization of the saturation in the serum of bled animals, the diminished donation remained unchanged.

[Trophic effect of testosterone on erythropoiesis in the mouse].

Some differences between erythropoietin biogenesis under the action of natural stimuli and that resulting from testosterone administration are commented. Evidences are presented suggesting that androgens, apart from amplifying erythropoietin production, might exert some action on the stroma as specific erythrocytic tissue. This action could be anabolic or trophic and not erythropoietin dependent, at least to some extent, its effect being applied on the quantitative erythropoietic homeostasis.