Publications by authors named "J L Rougier"
Background: 14-3-3 proteins are ubiquitous proteins that play a role in cardiac physiology (e.g., metabolism, development, and cell cycle).
View Article and Find Full Text PDFThe transient receptor potential melastatin 4 (TRPM4) ion channel is ubiquitously expressed. Dysregulation and/or functional mutations of TRPM4 lead to several diseases. Within our studies, we screened for TRPM4 inhibitors and identified small molecules that block TRPM4 in the low µM range.
View Article and Find Full Text PDFTRPM4 is a calcium-activated, voltage-modulated, nonselective ion channel widely expressed in various cells and tissues. TRPM4 regulates the influx of sodium ions, thus playing a role in regulating the membrane potential. In the heart, TRPM4 is expressed in both cardiomyocytes and cells of the conductive pathways.
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- The M2 protein of influenza A virus (IAV) plays a critical role in virus uncoating and maintaining the structure of hemagglutinin (HA), but bat IAV M2 proteins show significant differences in their amino acid sequences compared to conventional IAV, leading to potential functional variations.
- Research revealed that bat IAV M2 proteins are less effective at protecting HA from low pH changes, indicating lower proton channel activity, and specific mutations like N31S can make these proteins more sensitive to antiviral drugs like amantadine.
- The unique characteristics of bat IAV M2 proteins may help reduce their cytotoxic effects and inflammation, suggesting an evolutionary adaptation that allows these viruses to interact differently with their
Cardiac voltage-gated sodium (Na ) channels (Na 1.5) are crucial for myocardial electrical excitation. Recent studies based on single-channel recordings have suggested that Na channels interact functionally and exhibit coupled gating.
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