Publications by authors named "J L Ritt"
The protozoan parasite Leishmania has a large family of major facilitator membrane proteins part of the Folate Biopterin Transporter (FBT) family. The chromosome 10 of Leishmania has a cluster of 7 FBT genes including the S-Adenosyl methionine (AdoMet) transporter and the functionally characterized folate transporters FT1 and FT5. Six of the 7 FBT proteins coded by this locus are located at the plasma membrane as determined by gene fusions with the green fluorescent protein.
View Article and Find Full Text PDFArticle Synopsis
- - Neuroscience research is generating larger and more complex data sets, prompting the adoption of advanced data science tools, with Neurodata Without Borders (NWB) offering a standardized approach for managing and sharing neurophysiology data
- - The article discusses the implementation of NWB data science pipelines in the authors' labs, highlighting successes, challenges, and design decisions to aid in bridging experimental neuroscience and data science
- - Key insights include the importance of standardization in enhancing data awareness and transparency, as well as specific feature suggestions to improve the usability and sharing of NWB data among researchers
Article Synopsis
- Synaptic heterogeneity is essential for complex communication in neural circuits, and understanding it requires examining factors like voltage-gated calcium channel (VGCC) characteristics.
- The study reveals that VGCC abundance significantly predicts the variability in neurotransmitter release probabilities among synapses but not between different types of synapses.
- Additionally, the research shows that key VGCC regulators, Straightjacket and Bruchpilot, have lower levels at high-probability synapses, yet their abundance correlates with stronger neurotransmitter release, indicating a complex interplay between VGCCs and synaptic function.
As an evolutionarily ancient sense, olfaction is key to learning where to find food, shelter, mates, and important landmarks in an animal's environment. Brain circuitry linking odor and navigation appears to be a well conserved multi-region system among mammals; the anterior olfactory nucleus, piriform cortex, entorhinal cortex, and hippocampus each represent different aspects of olfactory and spatial information. We review recent advances in our understanding of the neural circuits underlying odor-place associations, highlighting key choices of behavioral task design and neural circuit manipulations for investigating learning and memory.
View Article and Find Full Text PDFNeuroscience research has evolved to generate increasingly large and complex experimental data sets, and advanced data science tools are taking on central roles in neuroscience research. Neurodata Without Borders (NWB), a standard language for neurophysiology data, has recently emerged as a powerful solution for data management, analysis, and sharing. We here discuss our labs' efforts to implement NWB data science pipelines.
View Article and Find Full Text PDF