Publications by authors named "J L Riopel"
Introduction: De novo donor-specific HLA antibody (dnDSA) are associated with poor outcomes. Whether this observation applies to both HLA class I and II dnDSA remains unclear.
Methods: We studied 1236 consecutive kidney recipients who had routine anti-HLA antibody surveillance post-transplant.
Article Synopsis
- Alport syndrome is linked to three genes (COL4A3, COL4A4, COL4A5) and is marked by kidney issues like glomerulosclerosis and changes in the glomerular basement membrane.
- A study reported a mother and son with COL4A5-related Alport syndrome, sharing unusual kidney biopsy results and a specific genetic variant (p.Gly1170Ser).
- Findings indicate that changes in collagen expression in Bowman's capsule might be more affected by mutations in COL4A5, suggesting that certain genetic variants can play a significant role in how the disease presents.
Article Synopsis
- Scientists studied the estrogen receptor α (ERα) in prostate cancer and found it only appears in about half of the patients' tumors.
- When ERα is present, it can affect how the cancer grows and spreads, and is linked to patients' chances of survival.
- The research suggests that targeting ERα could be a new way to treat prostate cancer by changing how cancer cells use energy.
Introduction: The process of immunization following vaccination in humans bears similarities to that of immunization with allografts. Whereas vaccination aims to elicit a rapid response, in the transplant recipient, immunosuppressants slow the immunization to alloantigens. The induction of CD4+CXCR5+ T follicular helper (Tfh) cells has been shown to correlate with the success of vaccine immunization.
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- RMND1 is a gene linked to serious mitochondrial disorders, primarily causing early onset encephalomyopathy, often leading to death within three years of birth, though milder cases have been noted in older individuals.
- The report highlights a unique case of a 61-year-old woman diagnosed with RMND1-related issues who had an active life despite various health complications, suggesting a broader clinical spectrum than previously recognized.
- This case challenges existing perceptions about the severity and life expectancy of RMND1-related conditions and emphasizes the need for a better understanding of the relationship between genetic anomalies and diverse health outcomes.