Mechanism of Nephrolithiasis: Does the Microbiome Play a Role?

Nephrolithiasis imposes a significant health care burden around the world. In the past decade, there has been considerable interest in the human microbiota in relation to the onset of nephrolithiasis. Most of the research has focused on degradation of oxalate, a known causative factor for nephrolithiasis, by bacteria in the gut.

Cefazolin shifts the kidney microbiota to promote a lithogenic environment.

Clinical studies of the urinary tract microbiome, termed urobiome, suggest a direct, antibiotic-dependent, impact of the urobiome on kidney physiology. However, evidence for kidney bacteria comes from indirect sources or infected tissue. Further, it is unclear how antibiotics impact kidney bacteria.

Molecular Evidence of Leptospira spp. Infection Among Household Dogs From 15 Municipalities of the Department of Caldas, Colombia.

Introduction: Leptospira spp. is a bacterial genus which includes pathogenic species that causes leptospirosis. Several animal species can harbour, shed and disseminate the bacteria through their urine.

Hazardous gas emissions from drop-in biofuels: mutagenicity, cytotoxicity, and unregulated pollutants.

This study investigates cancer-related mutations (TA98 and YG5185 strains/Ames test), cell death (human A549 cell line/MTT assay) and unregulated pollutants (16 PAH, 13 carbonyls) from the gas exhaust emissions from a last-mile delivery vehicle following the WLTC driving cycle, operating with hydrotreated vegetable oil and biodiesel. Both biofuels were used pure and blended 20 % by volume with diesel fuel. Gas phase samples were collected using XAD-2 Amberlite® resin.

Complex system modelling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria.

Decades of research have made clear that host-associated microbiomes touch all facets of health. However, effective therapies that target the microbiome have been elusive given its inherent complexity. Here, we experimentally examined diet-microbe-host interactions through a complex systems framework, centered on dietary oxalate.