End-To-End Automated Intact Protein Mass Spectrometry for High-Throughput Screening and Characterization of Bispecific and Multispecific Antibodies.

Bispecific antibodies (bsAbs) and multispecific antibodies (msAbs) represent a promising frontier in therapeutic antibody development, offering unique capabilities not achievable with traditional monoclonal antibodies. Despite their potential, significant challenges remain due to their increased molecular complexity. One prominent challenge is the correct assembly of light and heavy chains, as improper pairing leads to mispaired or incompletely assembled species that lack therapeutic efficacy and possess undesired properties, impairing the developability, manufacturability, and safety.

Modeling pH and Temperature Effects as Climatic Hazards in V and Planktonic Growth and Biofilm Formation.

Climate-induced stressors, such as changes in temperature, salinity, and pH, contribute to the emergence of infectious diseases. These changes alter geographical constraint, resulting in increased spread, exposure, and infection rates, thus facilitating greater -human interactions. Multiple efforts have been developed to predict exposure and raise awareness of health risks, but most models only use temperature and salinity as prediction factors.

Chlorophyll Fluorometer for Intelligent Water Sampling by a Small Uncrewed Aircraft System (sUAS).

We describe a waterproof, lightweight (1.3 kg), low-power (∼1.1 W average power) fluorometer operating on 5 V direct current deployed on a small uncrewed aircraft system (sUAS) to measure chlorophyll and used for triggering environmental water sampling by the sUAS.

VISTA is an acidic pH-selective ligand for PSGL-1.

Co-inhibitory immune receptors can contribute to T cell dysfunction in patients with cancer. Blocking antibodies against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) partially reverse this effect and are becoming standard of care in an increasing number of malignancies. However, many of the other axes by which tumours become inhospitable to T cells are not fully understood.

Electronic Visits For Common Acute Conditions: Evaluation Of A Recently Established Program.

Asynchronous interactions between patients and providers through patient portals (called e-visits in this article) have the potential to increase access to care and reduce the time requirements for some office visits. We performed a retrospective chart review for nonemergent acute care of adults in the period December 2015-July 2017 at the Medical University of South Carolina. Most patients in the 1,565 e-visits were female (80.