Comprehensive Single-Cell Immune Profiling Defines the Patient Multiple Myeloma Microenvironment Following Oncolytic Virus Therapy in a Phase Ib Trial.

Purpose: Our preclinical studies showed that the oncolytic reovirus formulation pelareorep (PELA) has significant immunomodulatory anti-myeloma activity. We conducted an investigator-initiated clinical trial to evaluate PELA in combination with dexamethasone (Dex) and bortezomib (BZ) and define the tumor immune microenvironment (TiME) in patients with multiple myeloma treated with this regimen.

Patients And Methods: Patients with relapsed/refractory multiple myeloma (n = 14) were enrolled in a phase Ib clinical trial (ClinicalTrials.

Telocytes regulate macrophages in periodontal disease.

Telocytes (TCs) or interstitial cells are characterised in vivo by their long projections that contact other cell types. Although telocytes can be found in many different tissues including the heart, lung, and intestine, their tissue-specific roles are poorly understood. Here we identify a specific cell signalling role for telocytes in the periodontium whereby telocytes regulate macrophage activity.

A Proposal for Evaluating Psychosocial Trauma.

Background: The objective of the study was to design and validate the Psychosocial Trauma Scale (ETAPS) for assessing psychosocial consequences of collective violence. This instrument proposed the following dimensions: Pre-traumatic Situation, Destruction of Fundamental Beliefs, Intergroup Emotions, and Family and Community Destruction.

Method: A total of 382 people participated who had been affected by political violence: civil war in El Salvador, forced displacement from Colombia and state violence from Chile.

GLP1 analogues among patients with overweight or obesity during lockdown.

Background And Objectives: One of the potential negative effects of a lockdown are changes in dietary and lifestyle patterns, which can lead to weight gain. Our objective was to assess the changes on dietary habits and eating patterns in a lockdown situation and their impact on weight. We aimed to determine whether the treatment with GLP1 analogues (aGLP1) could impact on these parameters.

AlInN on Si (100) Solar Cells (x = 0-0.56) Deposited by RF Sputtering.

We investigate the photovoltaic performance of solar cells based on n-AlInN (x = 0-0.56) on p-Si (100) hetero-junctions deposited by radio frequency sputtering. The AlInN layers own an optical bandgap absorption edge tuneable from 1.